GJA1-20K Reduces Levels of Interleukin-6 in Pigs with REBOA-Induced Ischemia-Reperfusion Injury
Introduction Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a resuscitation tool for noncompressible hemorrhage, preserving perfusion to the heart and brain while interrupting life-threatening blood losses. However, patients often suffer ischemia-reperfusion injury after balloon deflation. We previously demonstrated that the protein GJA1-20k protects the mitochondria and reduces serum interleukin-6 (IL-6), an inflammatory marker …